Feel Younger, Live Longer: 3 Simple Secrets Inside 🎁

In partnership with

Welcome back to ThriveWire!

Happy Boxing Day! 🎁 Whether you're enjoying leftovers, spending time with loved ones, or taking a well-deserved moment to relax, we’re here to help you make the most of this festive season with insights that can shape your health and longevity in the year ahead.

This week’s ThriveWire is going to help you to shape your genetic destiny and understand the impact of AI on healthcare.

Let’s get started!

Here’s what’s inside: 

• Epigenetics and Lifestyle 🧬 Learn how your daily choices, like diet, exercise, and stress management, can shape your gene expression and influence aging.

• Omega-3 Fatty Acids: Brain and Heart Health 🧠❤️ Discover the latest evidence on how omega-3s can reduce cognitive decline and cardiovascular risks, plus tips on choosing the right sources.

• The Future of Medicine 🤖 Explore how artificial intelligence is transforming healthcare, from personalized treatments to breakthroughs in longevity research.

• What Else is Happening This Week? 🤔 Rhonda Patrick shares insights on the limits of the human lifespan, Jose Cordeiro discusses his vision to end aging, and experts share their views on radical life extension.

Novaxidil Triple Action Hair Regrowth Treatment

Novaxidil is a Premium OTC Triple Action hair loss treatment that stimulates hair regrowth, prevents further loss, AND nourishes your scalp with a combination of clinically proven ingredients: 5% Minoxidil, 2% K-Conazole, 1% Nicotinamide, Vitamin K, Biotin, and Collagen Peptides.

Our team of MD/PhD's formulated Novaxidil to maximize results while minimizing side effects.

MINOXIDIL 5%: Minoxidil is the Gold Standard for hair regrowth. It achieves this by shortening the telogen phase, extending the anagen phase, increasing blood flow to the scalp, and increasing dermal papilla cell activity.

K-CONAZOLE™ 2%: Studies have shown that K-Conazole™, a proprietary version of the popular compound, blocks the production of dihydrotestosterone (DHT), a hormone linked to male pattern baldness, as effectively as prescription alternatives like FINA without the side effects. It works by inhibiting the 5-alpha reductase (5AR) enzyme, which converts testosterone into DHT.

NICOTINAMIDE 1%: Nicotinamide, also known as niacinamide, has potent effects on hair regrowth. In studies, it has been shown to increase blood flow, and reduce inflammation to the scalp, as well as prevent premature catagen entry, and increase hair thickness. Nicotinamide works in synergy with Minoxidil, and K-Conazole™ to maximize hair regrowth, and minimize loss like no other product on the market!

Before you give up, and start rocking the "bald look," give Novaxidil a try. We're confident you won't regret it.

Learn More

Epigenetics and Lifestyle: Shape Your Future Through Your Choices 🧬

Did you know your daily habits can influence how your genes behave? While your DNA provides the blueprint, epigenetics (the biological mechanisms that control gene expression) determines how those instructions are carried out.

The exciting part? Your lifestyle choices play a big role in shaping these mechanisms, which can impact aging and longevity.

How Epigenetics Works

Think of your genes as a piano and epigenetics as the sheet music. The piano remains the same, but the sheet music (your lifestyle) determines the melody. By making thoughtful choices, you can influence whether genes that promote health are "played" more often.

Lifestyle Choices That Influence Epigenetics

1. Diet: Nourish Your Genes: Certain foods can affect your epigenetic markers, enhancing longevity and reducing disease risk:

   • Cruciferous vegetables (like broccoli and kale): Rich in sulforaphane, which supports DNA repair.

   • Berries and green tea: Packed with polyphenols that protect against inflammation.

   • Omega-3 fatty acids: Found in salmon and walnuts, known to promote healthy gene expression.

2. Exercise: Rewriting Your Genetic Code: Physical activity doesn’t just improve fitness, it activates genes linked to metabolism and cellular repair:

   • Regular aerobic exercise boosts gene activity related to mitochondrial health.

   • Strength training helps regulate genes involved in muscle growth and insulin sensitivity.

3. Stress Management: Calm Your Genes: Chronic stress can alter epigenetic markers in ways that accelerate aging and increase disease risk. Combat this by:

   • Practicing mindfulness or meditation for just 10 minutes a day.

   • Engaging in activities that bring joy and relaxation, like reading or nature walks.

Why It Matters for Longevity

Epigenetic changes are reversible, meaning it’s never too late to improve your gene expression. Small, consistent lifestyle changes can switch on genes that promote longevity and switch off those linked to aging and disease.

Quick Wins to Support Healthy Gene Expression 🚀

• Start your day with a handful of walnuts or a green tea boost.

• Take a brisk 30-minute walk to activate longevity-promoting genes.

• Write down one thing you’re grateful for each day to lower stress hormones.

Did You Know?

Research in Nature Communications found that regular exercise can “reprogram” genes in as little as 6 months, enhancing cellular function and extending healthspan.

Your genes may set the stage, but your choices write the script. By optimizing your diet, staying active, and managing stress, you can harness the power of epigenetics to age with vitality.

Read this article for a deep dive into epigenetics

Omega-3 Fatty Acids: Evidence-Based Insights on Brain and Heart Health 🧠❤️

Omega-3 fatty acids, long celebrated for their potential health benefits, have been the subject of robust scientific scrutiny. New research reveals important nuances about their efficacy in reducing cognitive decline and cardiovascular disease (CVD) risk. Here’s what the latest studies tell us, and what it means for your health.

The Role of Omega-3s in Cognitive Health

A comprehensive analysis of 48 longitudinal studies, including data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI), highlights significant benefits of omega-3 fatty acids, particularly DHA and EPA, in reducing the risk of Alzheimer’s disease (AD) and cognitive decline. Key findings include:

• Reduced Risk: Long-term omega-3 supplementation was associated with a 64% lower risk of AD in the ADNI cohort.

• Dose Matters: For each 0.1 g/day increase in DHA or EPA intake, the risk of cognitive decline dropped by 8-10%.

• Biomarkers: Elevated DHA levels in the blood, particularly in erythrocyte membranes, correlated with a lower risk of cognitive decline.

Caveats: The benefits may be more pronounced in certain populations, such as those with the APOE E4 genetic risk factor for AD. While observational studies show clear associations, randomized controlled trials have yielded mixed results, suggesting that dosage and genetic differences may influence outcomes.

The Impact of Omega-3s on Cardiovascular Health

A meta-analysis of 38 randomized controlled trials involving over 149,000 participants sheds light on omega-3 fatty acids' effects on heart health:

• CVD Risk Reduction: Omega-3s, particularly EPA, were linked to significant reductions in cardiovascular mortality (RR: 0.93), non-fatal heart attacks (RR: 0.87), and major adverse cardiovascular events (MACE, RR: 0.95).

• EPA vs. EPA+DHA: EPA monotherapy showed more substantial benefits compared to combined EPA+DHA treatments, including a 28% reduction in coronary heart disease events.

• Risks: Supplementation was associated with a slight increase in atrial fibrillation and bleeding, particularly at higher doses of EPA.

Caveats: The cardiovascular benefits were more pronounced in individuals with elevated triglycerides or pre-existing CVD. The added risk of atrial fibrillation warrants caution for some populations.

Should You Supplement with Omega-3s?

Cognitive Health: If you're at risk of cognitive decline or have a family history of AD, incorporating DHA-rich omega-3s into your diet or supplement routine could be beneficial. Look for supplements with at least 500-1,000 mg of combined DHA and EPA, and consider long-term use for sustained benefits.

Cardiovascular Health: EPA-focused supplements (e.g., icosapent ethyl) appear to offer the greatest cardiovascular protection. Speak with your healthcare provider to determine if high-dose EPA is appropriate for you, especially if you have CVD or elevated triglycerides.

Dietary Sources of Omega-3s 🐟

For those who prefer to get omega-3s from food, these are your best bets:

• Fatty Fish: Salmon, mackerel, sardines, and anchovies are rich in EPA and DHA. Aim for 2–3 servings per week.

• Plant-Based Sources: Walnuts, flaxseeds, and chia seeds provide ALA, though its conversion to EPA/DHA is limited.

The Bottom Line

Omega-3s remain a valuable tool for promoting brain and heart health, particularly when tailored to individual needs. The strongest evidence supports their role in reducing risks for AD and specific cardiovascular outcomes in at-risk populations.

Supplements can be helpful but are not one-size-fits-all. If you're considering adding omega-3s to your routine, prioritize high-quality products and consult your healthcare provider to ensure they align with your overall health goals.

Read the evidence

The Relationship of Omega-3 Fatty Acids with Dementia and Cognitive Decline

Effect of omega-3 fatty acids on cardiovascular outcomes

The Future of Medicine: How Artificial Intelligence Will Transform Healthcare 🤖

Artificial intelligence (AI) is poised to revolutionize the way we approach healthcare and longevity. By accelerating drug discovery, personalizing treatments, and providing earlier disease detection, AI is rapidly becoming a cornerstone of modern medicine. But what does this mean for healthspan and longevity research? Let’s dive in.

Transforming Healthcare 🚀

AI is already reshaping how we diagnose, treat, and prevent diseases:

• Faster Drug Discovery: Traditional drug development can take over a decade, but AI algorithms are identifying promising compounds in a fraction of the time. For example, Insilico Medicine used AI to develop a drug candidate for idiopathic pulmonary fibrosis in just 46 days.

• Precision Medicine: By analyzing genetic data, AI enables highly personalized treatment plans tailored to your unique biology. This approach is already being used in cancer treatments, where AI helps predict how specific tumors will respond to different therapies.

• Earlier Detection: AI tools like Google's DeepMind have demonstrated the ability to detect diseases such as diabetic retinopathy and breast cancer earlier than human specialists. Early intervention is critical for improving outcomes and extending healthspan.

Advancing Longevity Research 🧬

AI isn’t just changing healthcare, it’s accelerating the quest to understand and combat aging:

• Biomarker Identification: AI is helping researchers pinpoint aging biomarkers, such as epigenetic changes or blood-based indicators. This allows scientists to measure biological age more accurately and test interventions faster.

• Repurposing Existing Drugs: AI has uncovered new longevity applications for existing drugs, like metformin and rapamycin, by analyzing vast amounts of biomedical data for hidden connections.

• Predicting Longevity Interventions: AI-powered models are testing theoretical interventions in silico (via simulations), reducing the time and cost required for lab-based research.

Practical Applications Today 🛠️

While the future of AI in medicine is dazzling, you don’t have to wait to benefit:

• AI-Powered Wearables: Devices like the Apple Watch and Oura Ring use AI to monitor heart rate variability, sleep quality, and activity levels, offering actionable insights to improve healthspan.

• Symptom Checkers: Tools like Ada Health use AI to analyze symptoms and suggest potential causes, empowering you to make informed decisions about your health.

• Genetic Testing Services: Companies like 23andMe and Helix employ AI to interpret genetic data, giving you insights into your predispositions for certain conditions and how to manage them.

Why It Matters ❤️

The integration of AI into healthcare is not just about treating diseases. It’s about preventing them, optimizing health, and extending both healthspan and lifespan. From pinpointing your biological age to discovering the next breakthrough in anti-aging treatments, AI is helping us understand and manage the aging process like never before.

As the technology evolves, the line between science fiction and reality continues to blur, bringing us closer to a future where healthcare is more accessible, personalized, and effective than ever.

What Else is Happening This Week? 🤔

• Is There a Limit To Human Longevity? Rhonda Patrick from Found My Fitness shares some fascinating insights in this video.

• Jose Cordeiro on Ending Aging: At RadFest, Jose Cordeiro, author of The Death of Death, highlighted exponential breakthroughs in biotech and AI that could combat aging as a disease.

• Radical Life Extension: Reality or Hype? Experts debate a recent Nature Aging article challenging the plausibility of radical life extension this century.

Thanks for Reading This Boxing Day Edition of ThriveWire! 🎁

As the holiday season winds down, it’s the perfect time to reflect on how we can enter the new year feeling healthier, sharper, and more purposeful.

Whether you’re relaxing after a festive feast or taking a moment for yourself amid the hustle and bustle, I hope this edition of ThriveWire has sparked ideas for a vibrant, longer life.

Got a favorite tip or topic you'd like us to cover in 2025? I’d love to hear your thoughts! And if ThriveWire brought value to your week, share it with someone who could use a little extra inspiration as we all look toward the year ahead.

Wishing you a joyful end to the year and an energizing start to the next!

"Health is the greatest gift." – Buddha

Stay healthy,
Andrew Courtney
Founder, ThriveWire

Sent this newsletter by a friend?

Disclaimer: The information provided in ThriveWire is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before making changes to your diet, exercise routine, or health regimen.

This Holiday Season, Give Yourself the Gift of Nike Air Max.

This winter, take your footwear game to the next level with Nike's Air Max collection for men. With a diverse range of models, this collection prioritizes comfort and functionality, perfectly tailored to meet your everyday needs. Whether you're hitting the gym or heading out for a casual outing, these sneakers deliver the support you crave without compromising on style.

Find the perfect pair that matches your lifestyle and get ready to make a statement with every step. Treat yourself to a fresh pair from the collection this holiday season—you deserve it.

Shop the Men’s Air Max Collection